Steroid Calculator - Corticosteroid Dose Conversion
Use this steroid calculator to convert oral and IV corticosteroid doses by anti-inflammatory potency, with mg, hydrocortisone reference, and dose factor.
Steroid Calculator
Results
What Is a Steroid Calculator?
A steroid calculator is a clinical reference tool that converts a corticosteroid dose from one drug to another by adjusting for the relative anti-inflammatory potency of each option, so the new mg delivers the same glucocorticoid effect. The result panel shows the target dose in mg, the hydrocortisone-equivalent mg, and a relative dose factor.
- • Switch between intermediate-acting oral steroids: translate a prednisone prescription to methylprednisolone, prednisolone, or triamcinolone.
- • Step down from a long-acting IV steroid: convert a dexamethasone IV dose to an oral prednisone or hydrocortisone equivalent.
- • Reference adrenal insufficiency replacement therapy: compare any corticosteroid dose against the 20 mg hydrocortisone reference.
- • Plan a taper between different drugs: use the dose factor to plan a step-down across drugs of different potencies.
Corticosteroid switches are common because prednisone, methylprednisolone, dexamethasone, and hydrocortisone are interchanged for cost or route reasons. The FDA-approved DailyMed label for Deltasone (prednisone) lists an initial adult dose range of 5 mg to 60 mg per day, and names hydrocortisone or cortisone as the first choice for adrenocortical insufficiency.
When the same patient needs an adrenal CT or MRI reviewed alongside the corticosteroid dose plan, adrenal washout calculator classifies an adrenal lesion against the absolute and relative percentage washout thresholds so the imaging and steroid work-up can be reviewed together.
How the Steroid Calculator Works
The conversion is built on a single equation: multiply the current dose by the current drug's potency, then divide by the target drug's potency. The potency table comes from the NADF corticosteroid comparison chart.
- Current drug: The corticosteroid being switched from, selected from hydrocortisone, cortisone, prednisone, prednisolone, methylprednisolone, triamcinolone, dexamethasone, or betamethasone.
- Current dose (mg): The per-dose amount in milligrams. Enter the per-dose amount, not the daily total. The input range is 0.01 to 1000 mg.
- Target drug: The corticosteroid being switched to, selected from the same eight-drug list.
- Anti-inflammatory potency: A relative index where hydrocortisone = 1, cortisone = 0.8, prednisone and prednisolone = 4, methylprednisolone and triamcinolone = 5, dexamethasone and betamethasone = 30.
The dose factor output is the easiest sanity check. A factor above 1 means the target drug is more potent per mg, so the new mg is smaller than the current mg; a factor below 1 means the target drug is less potent per mg, so the new mg is larger than the current mg.
Prednisone 5 mg to methylprednisolone
Prednisone (potency 4), 5 mg, to methylprednisolone (potency 5).
Hydrocortisone-equivalent = 5 x 4 = 20 mg. Target dose = 20 / 5 = 4 mg. Dose factor = 1.25.
Target dose = 4 mg, hydrocortisone-equivalent = 20 mg, dose factor = 1.25.
A 5 mg prednisone tablet equals a 4 mg methylprednisolone tablet, the standard adult step-down between intermediate-acting steroids.
Prednisone 20 mg to dexamethasone
Prednisone (potency 4), 20 mg, to dexamethasone (potency 30).
Hydrocortisone-equivalent = 20 x 4 = 80 mg. Target dose = 80 / 30 = 2.67 mg. Dose factor = 7.5.
Target dose = 2.67 mg, hydrocortisone-equivalent = 80 mg, dose factor = 7.5.
A 20 mg prednisone dose drops to 2.67 mg of dexamethasone. The 7.5x factor is the number to confirm when switching between intermediate and long-acting steroids.
According to National Adrenal Diseases Foundation (NADF) healthcare-professional resources, the corticosteroid comparison chart used to translate between oral and IV steroids anchors hydrocortisone at a potency of 1 (20 mg), cortisone at 0.8 (25 mg), prednisone and prednisolone at 4 (5 mg), methylprednisolone and triamcinolone at 5 (4 mg), and dexamethasone and betamethasone at 30 (0.75 mg and 0.6 mg).
The potency-adjusted mg approach used here is the same one clinicians use when switching between benzodiazepines of different strength, so benzodiazepine conversion calculator shows the equivalent diazepam mg for a lorazepam or clonazepam dose in the same one-screen workflow.
Key Concepts Explained
Four short definitions make the page easier to follow when comparing prednisone, hydrocortisone, and dexamethasone.
Anti-inflammatory potency
A relative index that compares the glucocorticoid effect of one corticosteroid against hydrocortisone. Hydrocortisone = 1, cortisone = 0.8, prednisone and prednisolone = 4, methylprednisolone and triamcinolone = 5, dexamethasone and betamethasone = 30.
Hydrocortisone-equivalent mg
The number of hydrocortisone mg that would deliver the same anti-inflammatory effect as the current dose. It is the intermediate step in every corticosteroid conversion.
Duration of action
The biological half-life of the glucocorticoid effect. Short-acting steroids last 8 to 12 hours, intermediate-acting 12 to 36 hours, and long-acting 36 to 54 hours.
Dose factor
The ratio of the current dose to the target dose. A factor above 1 means the new drug is more potent per mg, so the target mg is smaller; a factor below 1 means it is less potent per mg, so the target mg is larger; and a factor of 1 means the two drugs share potency.
These four concepts feed every number the calculator shows. The potency index does the math, the hydrocortisone-equivalent mg makes the result comparable with reference guidance, and the dose factor is the easiest sanity check.
When a patient on chronic corticosteroid therapy also needs a potency-adjusted opioid switch, opioid calculator returns the morphine-equivalent daily mg for the same oral or IV input.
How to Use This Steroid Calculator
The calculator runs the potency math. Pick the current drug, type the per-dose mg, and pick the target drug.
- 1 Pick the current corticosteroid: Select the drug you are switching from.
- 2 Type the per-dose mg: Enter the per-dose amount in mg, not the daily total. For a 20 mg prednisone tablet, type 20.
- 3 Pick the target corticosteroid: Select the target drug; the result panel updates as soon as the selection changes.
- 4 Read the target dose in mg: Note the Target corticosteroid dose row, which shows the potency-adjusted mg in the new drug. The prescribing decision still belongs to the clinician, who reviews the new mg against the disease-specific FDA label, the dosing-frequency change, and the patient context.
- 5 Sanity-check with the dose factor: A factor well above 1 means the target drug is stronger per mg, so the new mg is smaller than the current mg. A factor well below 1 means the target drug is weaker per mg, so the new mg is larger than the current mg.
- 6 Compare against the hydrocortisone reference: The Hydrocortisone-equivalent mg row shows the same effect in plain hydrocortisone, the unit used in adrenal insufficiency guidance.
Prednisone 5 mg to methylprednisolone shows target dose 4 mg, hydrocortisone-equivalent 20 mg, dose factor 1.25, current potency 4, and target potency 5. Change the target to dexamethasone and the panel updates to target dose 0.67 mg, dose factor 7.5, and target potency 30.
When the same switch is paired with a neuropathic pain regimen, gabapentin dosage calculator returns the per-dose mg and daily ceiling for gabapentin so both plans can be reviewed in one session.
Benefits of Using This Steroid Calculator
A steroid calculator replaces a manual cross-multiplication with a readable result that lists the new mg, the hydrocortisone-equivalent mg, and a dose factor.
- • Replaces manual cross-multiplication: the math is done for every drug pair.
- • Surfaces the hydrocortisone-equivalent mg: the same effect in plain hydrocortisone mg is shown alongside the target dose, the unit used in adrenal insufficiency guidance.
- • Flags the dose factor for safety: the dose factor row makes it obvious when the new drug is much stronger or weaker per mg, the most common source of dose errors.
- • Pairs with other dosage calculators: the converted mg can be reviewed against the gabapentin, tramadol, or other reference dose calculators in the health-fitness cluster.
- • Covers the eight most common oral and IV steroids: hydrocortisone, cortisone, prednisone, prednisolone, methylprednisolone, triamcinolone, dexamethasone, and betamethasone are on the same screen.
These benefits show up most when the prescriber is switching between drugs of different potencies. Pairing the calculator with a benzodiazepine or opioid conversion tool gives the same potency-adjusted read-out for other drug classes.
When a clinician is reviewing an analgesic plan alongside a corticosteroid taper, tramadol dosage calculator returns the per-dose mg and daily ceiling for the analgesic so both dose plans can be checked together.
Factors That Affect Your Results
The potency math is stable, but the clinical context is not. Five factors and two limitations drive the visible result and the dosing plan that follows it.
Route of administration
The potency index is for oral or IV dosing. Topical, inhaled, and rectal steroids have different effective potencies because of absorption.
Duration of action
Short-acting steroids last 8 to 12 hours, intermediate-acting 12 to 36 hours, and long-acting 36 to 54 hours, so a switch from dexamethasone to hydrocortisone has to add doses per day.
Mineralocorticoid activity
Hydrocortisone and cortisone carry meaningful mineralocorticoid activity, while methylprednisolone, triamcinolone, dexamethasone, and betamethasone have none, so a switch can change fluid balance and blood pressure.
Liver function and prodrug activation
Prednisone is a prodrug the liver converts to prednisolone. Patients with liver impairment may not convert the full dose, so a switch to prednisolone keeps the per-dose mg the same.
Patient age and weight
Adult and pediatric reference doses differ, and the calculator does not adjust for body weight. A 5 mg prednisone dose fits many adults but sits well above the per-kg pediatric reference, so use a weight-based calculator for pediatric prescriptions.
- • The calculator returns a potency-adjusted mg, not a treatment recommendation. The new mg should still be reviewed against the disease-specific FDA label and the patient's clinical context before any change is made.
- • The result is for oral or IV administration only. Topical, inhaled, and rectal steroids have different effective potencies because of absorption, so the calculator's mg should not be applied to those routes.
These factors and limitations explain why the calculator is a reference tool, not a prescribing engine. The FDA-approved label for the chosen drug remains the primary reference for any clinical decision.
According to DailyMed / FDA Deltasone (prednisone) tablet label, the initial adult dose may vary from 5 mg to 60 mg per day depending on the disease being treated, and the same total glucocorticoid effect can be reached with a different corticosteroid when the potency-adjusted dose is used.
According to DailyMed / FDA dexamethasone label, the usual adult dose range is 0.5 mg to 9 mg per day depending on the indication, and dexamethasone is a long-acting glucocorticoid with no mineralocorticoid activity.
For a patient on long-term corticosteroid therapy whose renal function is also being reviewed, creatinine clearance calculator estimates creatinine clearance from age, weight, and serum creatinine so the steroid taper and any renally cleared adjunct can be checked together.
Frequently Asked Questions
Q: What is a steroid calculator used for?
A: A steroid calculator converts a corticosteroid dose from one drug to another by adjusting for the relative anti-inflammatory potency of each option, so the new mg delivers the same glucocorticoid effect. The result panel shows the new mg, the hydrocortisone-equivalent mg, and a dose factor for sanity checking.
Q: How do I convert prednisone to methylprednisolone?
A: Multiply the prednisone dose in mg by 4, then divide by 5, because prednisone has a potency of 4 and methylprednisolone has a potency of 5. A 5 mg prednisone tablet equals 4 mg of methylprednisolone, and the dose factor stays at 1.25 across the range.
Q: What is the equivalent dose of dexamethasone compared with prednisone?
A: Dexamethasone has a potency of 30, which is 7.5 times the potency of prednisone at 4. Five mg of prednisone equals 0.67 mg of dexamethasone, and 20 mg of prednisone equals 2.67 mg of dexamethasone. The 7.5x dose factor is the most important number to confirm during a switch.
Q: What is the difference between short, intermediate, and long acting corticosteroids?
A: Short-acting steroids (hydrocortisone, cortisone) last 8 to 12 hours, intermediate-acting steroids (prednisone, prednisolone, methylprednisolone, triamcinolone) last 12 to 36 hours, and long-acting steroids (dexamethasone, betamethasone) last 36 to 54 hours, so dosing frequency has to change when the drug changes.
Q: How do I switch between hydrocortisone and prednisone safely?
A: Hydrocortisone has a potency of 1, prednisone has a potency of 4, and the 20 mg hydrocortisone reference used in adrenal insufficiency guidance is equivalent to 5 mg of prednisone. Forty mg of hydrocortisone equals 10 mg of prednisone, and 100 mg of hydrocortisone equals 25 mg of prednisone.
Q: Does the calculator account for dosing frequency or half-life?
A: The calculator returns a potency-adjusted per-dose mg, not a daily total, and it does not change the number of doses per day. A switch from dexamethasone to hydrocortisone has to add doses per day because dexamethasone lasts 36 to 54 hours and hydrocortisone lasts 8 to 12 hours.